Abstract: The accelerated evolution of information technology (IT) has compelled organizations to adopt structured governance frameworks to enhance audit efficacy and ensure robust information security. This study presents a systematic literature review examining the integration of COBIT and ISO/IEC 27001 within IT audit practices. Employing a qualitative descriptive methodology, the review synthesizes insights from seven primary scholarly sources, including case studies from both public and private sectors. The analysis delineates integration patterns, identifies best practices, and explores the synergistic potential of aligning COBIT’s strategic governance capabilities with the technical control rigour of ISO/IEC 27001. Findings demonstrate that such integration enhances audit capability maturity, facilitates structured risk mitigation, and fosters alignment between IT functions and organizational objectives. Nonetheless, notable research gaps persist, particularly the scarcity of quantitative assessments, limited cross-sector generalizability, and the absence of longitudinal evaluations of implementation outcomes. Additionally, practical challenges—including integration complexity, inadequate human resource competencies, and the lack of standardized implementation guidelines—impede broader adoption. The study concludes that integrating COBIT and ISO/IEC 27001 constitutes a viable foundation for advancing IT governance and audit maturity. However, further empirical investigation and development of pragmatic toolkits are essential. These insights aim to inform auditors, IT governance professionals, and policy makers in devising adaptive, standard-aligned audit strategies.